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DRV2667: DRV2667

Part Number: DRV2667

How is it that the DRV2667 when powered from 3V3 or 5V can output > 100V to drive an actuator?

How is this amplification beyond the supply rail possible?

Also, what would be the impact if the DRV2667 was driven by a single-ended analogue input?

Thank you