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TPS61378-Q1: 3.3V to 5V boost

Part Number: TPS61378-Q1

Hi, Is it possible to boost 3.3V to 5V with this device without entering the down-mode? because there is headroom on ISO- FET in certain condition and it reduces efficiency i want to know if this is possible.

Also please tell me if shorting ISO-FET (short OUT and Vo) is possible.