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TPS561208: Power multiplexing best practice

Part Number: TPS561208

Hello,

We use a TPS561208 to convert 12V power supply into 5V output and further down to 3.3V ouput with LDO to power the MCU. 

At the same time, we have another power source coming from USB and the requirement is to power the MCU with only USB source without the 12V power supply available.

My question is if the 12V power supply is not there and TPS561208 is not enabled in this case. Does the applied +5V from USB could possible damage any preceding circuit? like the TPS561208 in this case?

Thanks