I use part "TPS2493PWR" in following schematic:

Unom = 48V
UOV@48V ≥ 60V Overvoltage threshold
UUV = not defined Undervoltage threshold
ILimit(nom) = 4.16A Steady-state load current
ILimit = 1.2 * ILimit(nom) = 5A
TA(max) = 60°C Max. ambient temperature
TJ(max) = 125°C Max. static junction temperature
TJ2(max) = 150°C Max. transient junction temperature
Here is my calculation file: TPS249x_8x_Design_Calculator_REV_B.xlsx
The problem is that the TPS2493 or the MOSFET may break in the event of an overcurrent or short circuit. The fault is that the MOSFET heats up quickly to approx. 80-130°C immediately after the event. I test the outputs with an electronic load. The overcurrent event is triggered as calculated between 4.9-5.2A. The short circuit is also detected correctly.
This circuit part is present 6 times on a PCB. Out of 10 prototypes or 60 circuit parts, approx. 12% of the controller or MOSFET fails on different circuit parts.
Finally, I was able to repair them all by replacing the TPS2493 and MOSFET, sometimes multiply times. I also tried to change the values of the surrounding components. In the end, replacing the components mentioned led to success.
Once the outputs have been tested correctly, they always work.
What I would like to mention about the schematic is that the TVS diode D15 is only present once on a circuit board and is located near the input connection. This means that it is not located directly next to the respective TPS2493 circuit parts.
Thanks for your support.
Best regards,
Livio