We have 5 boards we have built with this design. Two of them are showing signs of failure. One is working fine.
One of the boards that failed shows a short on the VCAP net to ground. The VBAK net show 14K to ground. After removing U10, the short is gone. This indicates to me that U10 was damaged.
C53 (68uF, 1206, 10V) is as close to pin 3 as I could get it, about 170 mils.
C52 (10uF, 0402, 10V) is the input cap.
I am not sure what event caused the failures or why some boards work fine while others are seeing failures.