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Hello Patrick ,
Could you provide more details on item 1?
The compensation values Rcomp and Ccomp depend on the operating conditions and output capacitor value and ESR. See table 2 of the datasheet on page 12. Also, you can utilize the online simulation tool. See the WEBENCH panel on the right hand side on the product folder web page: http://www.ti.com/product/lmz10505
You can enter your specifications and create a design with the recommended BOM and compensation values.
On item 2, I am not aware of any limit on on/off cycles. As long as the conditions meet the operating ratings of the part, the test seem ok.
Regards,
Denislav