BQ24133: Can the system be connected directly to the 2 cell battery?

Team, 

The BQ24133 datasheet states: 

For 1-cell applications where the battery is not removable, the system can be directly connected to the battery to simplify the power path design and reduce the cost. With this configuration, the battery can automatically supplement the system load if the adapter is overloaded.

Is there anything that prevents us from doing the same for 2 cell applications? 

Thanks

Viktorija