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BQ78350-R1: Meaning of: "SMB is required for gauge setup. Signals would require isolation circuit for use in system"

Part Number: BQ78350-R1

On page 14 of http://www.ti.com/lit/ds/symlink/bq78350-r1.pdf it says "SMB is required for gauge setup. Signals would require isolation circuit for use in system" by the SMBUS connector. Can you further explain this requirement please?

Thanks, 
JP