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BQ35100: About an external NTC use case

Part Number: BQ35100

Hello team,

I may not understand well about a common sense for gauges, but let me ask a question below.
For an external NTC temperature measurement, it looks there are several variation elements which can generate a center shift such the bias(=REG25), internal pull down resistor and so on.
Is the BQ35100 expected to be calibrated by each part or each board in production to mitigate the center shift?
If yes, what is the best operation to calibrate?

Thanks in advance.
S.Sawamoto