HDC2080: HDC2080 vs HTU21D

Hello Chen,

The devices are mostly pin to pin from a hardware stance.  Note that the HDC2080 also includes an ADDR pin(pin 3), which must be tied high or low and also DRDY/INT, which could be ignored if you don't need to use this pin.   

From an interface/software stance, the devices are not compatible and the software would need to be implemented for HDC2080.  You can find MCU agnostic code examples and configurations below. 

https://www.ti.com/tool/download/ASC-STUDIO-HDC2080/1.0