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OPT101: How can i reduce 60Hz noise?

Part Number: OPT101

Hi, i use opt101 to measure blood flow.

I make circuit  bipolar supply +-5V with 0.1uF bypass cap, common pin to GND.

Light source is 250Hz PWM.

when I use 1M ohm internal resister, 60Hz noise is not occur.

But, when I use series resistor (datasheet 4.(a)) 5M ohm with 10pF 60Hz noise is occur.

How can i reduce this 60Hz noise? (use not notch filter, only OPT101)