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AFE4404: SPO2 measurement

Part Number: AFE4404

Dear TI Expert,

One of my customer has finished prototype based on AFE4404 for SPO2 measurement , they have encountered below two questions,

1) When measuring on same person's different wrist's position, they found that the radio of DC value of Red Vs. IR  were changing. This will influence the stability of measurement. How can they adjust some parameter to eliminate this influence?

2) some times, AC signal is very weak, and when amplifying the AC signal by increasing TIA_GAIN, once approached 100K gain, the DC value of IR will be saturated(closed to 2^21). How can they accomplish higher gain than 100K without saturation of IR's DC value?

Thanks a lot.