Hello,
Base on the next configuration, DRDY pin goes high every time HDC2080 sense higher than 31 C degrees but I'm not able to get the pin back to zero after reading TH_STATUS as it says in section 8.3.5.1 from spec. Is there something else that I'm missing?
//Define Register Map
#define TEMP_LOW 0x00
#define TEMP_HIGH 0x01
#define HUMID_LOW 0x02
#define HUMID_HIGH 0x03
#define INTERRUPT_DRDY 0x04
#define TEMP_MAX 0x05
#define HUMID_MAX 0x06
#define INTERRUPT_CONFIG 0x07
#define TEMP_OFFSET_ADJUST 0x08
#define HUM_OFFSET_ADJUST 0x09
#define TEMP_THR_L 0x0A
#define TEMP_THR_H 0x0B
#define HUMID_THR_L 0x0C
#define HUMID_THR_H 0x0D
#define CONFIG 0x0E
#define MEASUREMENT_CONFIG 0x0F
#define MID_L 0xFC
#define MID_H 0xFD
#define DEVICE_ID_L 0xFE
#define DEVICE_ID_H 0xFF
#define ADDR 0x40
#define HDC2080_ICR_DRDY_ENABLE 0x80
#define HDC2080_ICR_TH_ENABLE 0x40
#define HDC2080_ICR_HH_ENABLE 0x10
#define HDC2080_SOFT_RES 0x80
#define HDC2080_AMM 0x20 // 1/60 Hz (1 sample every minute)
#define HDC2080_DRDYINT_EN 0x04
#define HDC2080_INT_POL 0x02
#define HDC2080_MEAS_TRIG 0x01
void HDC2080_initialize(){
uint8_t data = 0;
/*
* Configuración para registro INTERRUPT_CONFIG
* TH_ENABLE = 1
*/
data = HDC2080_ICR_TH_ENABLE;
i2c_master_write_slave(ADDR, INTERRUPT_CONFIG, data, 1);
i2c_master_read_slave(ADDR, INTERRUPT_CONFIG, &data, 1);
printf("Registro 0x07 = %X\n", data);
/*
* Configuración para registro TEMP_THR_H
* Límite de temperatura inicial = 40 C
* Este valor se cambiará más adelante para ajustar al valor del ambiente
* Valor de 0x6E calculado con fórmula en Spec
*/
data = 0x6E;
i2c_master_write_slave(ADDR, TEMP_THR_H, data, 1);
i2c_master_read_slave(ADDR, TEMP_THR_H, &data, 1);
printf("Registro 0x0B = %X\n", data);
/*
* Configuración para registro Reset and DRDY/INT
* DRDY/INT_EN = 1
* INT_POL = 1
* INT_MODE = 1
*/
data = HDC2080_DRDYINT_EN | HDC2080_INT_POL | HDC2080_INT_MODE;
i2c_master_write_slave(ADDR, CONFIG, data, 1);
i2c_master_read_slave(ADDR, CONFIG, &data, 1);
printf("Registro 0x0E = %X\n", data);
}
By the way, I found previously an error in the published spec: 
Regards,
Pascal.
