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LMP91000: LMP91000 operation using an external resistance between C1 & C2 pins

Part Number: LMP91000

I am using the LMP91000 in 3 lead amperometric mode. After trying out using the internal TIA resistance values and verifying the gains, I tried out TIACN = 0x00 and with an external resistance of 330kohm.

I was quite surprised that the output changed quite a lot from the case with TIACN=0x1C (350kohm internal resistance). The big surprise was that pin C2, which looks like it is connected to the output of the TIA, comes up with quite a different voltage to the Vout pin. I thought these two should follow one another?

Are there any circumstances in which the voltages on C2 & Vout can separate, other than temp measurement  mode which I am not using?