TS5A623157: 2channels,2:1 SPI MUX

Hey Frank,

The TS5A623157 will certainly be able to support SPI signals. Any device that meets the bandwidth and voltage requirements for your design will work. After all, TI multiplexers are passive devices. The reason this isn't listed as a 'supports SPI signals' is due to the pinout of SPI. SPI is a 4 wire protocol so you'll need 4 channels. This is the same reason that the device is listed as 'Supports I2C signals'. I2C is a 2 wire protocol so a 2 channel 2:1 works there.
I would recommend a 4 channel 2:1 device instead for SPI muxing. Take a look at these:

https://www.ti.com/switches-multiplexers/analog/products.html?pqs=paqs&familyid=520#p1143=2:1%20SPDT&p480=4

TMUX1574 and TMUX1575 are common devices we've seen used for SPI multiplexing. The main difference here is that TMUX1575 will support 1.2V logic vs 1.8V logic on the 1574. Note that both these devices can support 2x VDD on the I/O lines as well and have integrated pulldown resistors on the control pins.

Let me know if you have any more questions!

Thanks,
Rami