I'm using 2x TMUX1575YCJ in a development board.
Their used between:
SPI/QSPI flash, which is connected to Dx ports,
A host, which is connected to SxA ports,
and, a header, which is connected to SxB ports.
Some of the SxB pins are unused and are floating while their corresponding SxA ports are connected to the host (see attached scheme).
Reason for them kept float is since grounding them would affect the Flash.
I wanted to make sure leaving these pins float won't affect the MUX behavior in different states nor cause damage over time.