SN74CBTLV3245A: Can SN74CBTLV3245APWR be used for I2C signals?

Yes. You can use any switch that has a low enough Ron and supports the desired voltage.

Hello Hanbo,

The SN74CBTLV3245APWR can be used for I2C signals, but we usually recommend 2:1 devices for I2C use cases since it is a 2-wire protocol. The SN74CBTLV3245APWR is an 8 channel 1:1, which still can be used if 4 channels are indicated for the protocol.  

If you have any more question regrading I2C please let me know or feel free to look at our FAQ: https://e2e.ti.com/support/switches-multiplexers-group/switches-multiplexers/f/switches-multiplexers-forum/1063475/faq-what-analog-switch-multiplexer-should-i-use-for-i2c-applications 

Thanks,

Nir