TS5A3159A: Tolerance of Pin1

ESD events are much shorter than 200 ns. The absolute maximum ratings do not allow more than 5.5 V if the current is not limited to less than 50 mA.

Hi Rayna,

The A version of this devices (as opposed to TS5A3159 without the A at the end) doesn't have the same esd cell on the I/O's that go up to the supply. Otherwise the isolation in V+ = 0 wouldn't work. If you limit the current it may reduce the likelihood of damaging the device but there won't be any guarantee since it would exceed the abs max. 
If they don't want the isolation in V+ = 0 then they could use the non-A version and do what Clemens said. Limit the current and it'll be fine.

Thanks,
Rami

Hi Ruixin,

There is not ESD cell from the I/O to supply. Only from I/O to GND. If you want protection for overvoltage events, you'll need to add external protection

Thanks,
Rami