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TMUX121: Requesting Part Detail

Part Number: TMUX121

Tool/software:

Dear TI Team,

We are using TMUX121 in our design. The datasheet shows typical application as I2C or I3C.
I am planning to use it single ended data signals as well differential ended clock signals.

I have two questions:

1.Is this device is only applicable I2C or I3C applications ?

2.Can the TMUX121 powered with 1.8V supply ?