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PMP22339: Using for 320VDC/20A , ( IN 280-360VDC )

Part Number: PMP22339
Other Parts Discussed in Thread: PMP22650

Tool/software:

1-Can we use this design for 20A 320VDC OUT with input range of 280-360VDC,Which components do i need to resize.

2-Can I get provide +/-160VDC isolated voltage regulation design.