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LM5122 - PMP7970 PSE power solution

Other Parts Discussed in Thread: LM5122, PMP7970

Dear Sir

LM5122 PMP7970 is a 54Vout/2.5A boost solution ,I guess it's a PSE 54V supply reference design ,Am I right ?

But I see many 54Vout schematic will use "isolation" boost solution for PSE application

My question is - If I would like to do 54Vout for PSE ,should I use Isolation boost solution or non-isolation boost solution ,Could I use PMP7970 on my PSE desing ?