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CC2541: Pin definition difference between CC2541/CC2541Q1

Part Number: CC2541


Hi, 

customer would like to migrate CC2541Q1 board to CC2541 industrial version. 

but looks the Pin1 and Pin4 connection is different.  floating vs. grounding. especially, the Pin4, marked with N.C. on CC2541 but GND on CC2541Q1. 

if customer just do the simple replacement without layout/sch changes, will it have issue? 

BR. Albin