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Hi,
You are correct, when using CC2640R2 with the BLEStack, we recommend leveraging QDID-180401.
The BLEStack on CC2640R2 supports Bluetooth 4.2 features only, and is Bluetooth 5.1 qualified. It means that, technically, your product will receive Bluetooth 5.1 qualification.
From a testing point of view, no change should be expected as long as you declare support for the proper features (Bluetooth 4.2 Privacy, Secure Connections, Data Length Extension) and make sure to remove non-supported features (such as Coded PHYs, LE 2M PHY, AoA CTE Rx/Tx, Advertising Extension).
Last but not least, I would like to highlight QDID 180401 is an End Product Listing. It means you should double check with your BQC whether you could limit the testing (see §2.1.1.2 of https://www.ti.com/ble-qualification).
I hope this will help,
Best regards,