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How to drive the CC2540 USB dongle through the ttyACMx interface w/o BlueZ

Other Parts Discussed in Thread: CC2540

Here is the setup: 

On an embedded system running Linux which doesn't have BlueZ installed, plug in the CC2540 USB dongle and mapped it to the /dev/ttyACM0 device.

What we want is to drive this CC2540 USB dongle by sending commands to it through the USB based /dev/ttyACM0 interface. Is this doable? If no, why?

If this is doable, what kind of commands can be used, any sample code available? Thanks !