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How to handle DVDD_USB of CC2540 in self-powered mode?

Other Parts Discussed in Thread: CC2540

We want to use the USB port of the CC2540 for programming purposes, but the board is self-powered.  Should we tie DVDD_USB to the board's power supply?  Or does the CC2540 use the appearance and disappearance of DVDD_USB to tell it that it's connected to a USB Host, such that we need to have DVDD_USB connected (via an LDO) to VBUS?

Thanks,

Scott