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CC2650: Custom board with bad Rx performance

Part Number: CC2650
Other Parts Discussed in Thread: , CC2640

I have a CC2650 4x4mm based custom board with simple_peripheral example running. Everything on the board works fine; I am able to connect, transmit and receive. There is however one issue which I don't understand with respect to Rx performance. 

When the board is advertising I have good enough range (say 10ft indoors). But when the board connects to the a CC2650STK based evaluation module running simple_central, I cannot have more than 10cm distance between the custom board and the CC2650STK board. 

The fact that the advertising mode has good range (only Tx on the custom board is On) but an established connection (required both Tx/Rx) has less than 10cm range, it tells me that something is off with the Rx performance of the board. How do I figure out what is going on?

I have attached the RF layout of the board along with schematic. The CC2650 device is configured with internal bias differential input RF signal chain.