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CCS/CC2650: Code on cc2650 does not start when external power supply is applied

Part Number: CC2650
Other Parts Discussed in Thread: CC1350

Tool/software: Code Composer Studio

I am trying to run a simple led blink on my customised board using cc2650, it works when run through the debugger but when external power supply is connected it is not working.

Is it a problem of hardware or software?

thanks and regards 

amit