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CC2541: CC2541 goes dead after frequently power on

Part Number: CC2541

test a CC2541 board, power on and off every 1 second,  like a user plugs on/off the device to power connector, then, several minutes later, it goes dead.   

I read out the hex from the chip, find it is different from the hex at first (before dead).

the software has comment out flash read/write, so no flash read/write in software. (at least in application level, do not know low level bluetooth stack).

how to solve this problem?