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CC2564MODA: Questions about layout, etc.

Part Number: CC2564MODA

Hi

My customer is planning to use CC2564MODA.
http://www.ti.com/lit/ds/symlink/cc2564moda.pdf

Q1) According to data sheet page#32, 4 layer PCB stack-up is recommended.
Customer prefers to use 2 layer.
What kinds of problems are expected if customer uses 2 layer instead of 4 layer?

Q2) On page#35, data sheet says;
“In addition, consider the proximity of the antenna to the enclosure and consider the enclosure material.”
Does customer need to consider cable harnesses position around the antenna?
There are cable harnesses(power, signal) inside customer product.
If so, how these cables need to be far from the antenna?

Thanks and regards,
Koichiro Tashiro