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Compiler/CC2640R2F: CC2640R2F128

Part Number: CC2640R2F

Tool/software: TI C/C++ Compiler

now my basic define as 

#define MAX_PDU_SIZE     27   

#define MAX_NUM_PDU  6 

#define DEFAULT_DESIRED_MIN_CONN_INTERVAL 16 
#define DEFAULT_DESIRED_MAX_CONN_INTERVAL 32

my program can run normally  but  when i change  

#define MAX_PDU_SIZE     230  

#define MAX_NUM_PDU 1

the program  can not run normal lost pocket is always occour , is there any other Define Need to Change?

      thanks!