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Hi Johny,
Please review the Smart RF Studio Help Documentation and Technical Documentation. Transceivers like the CC2500 require a SPI interface with a USB MCU to handle the request and apply the appropriate read/write commands. SoCs use the same SW library on the PC side and the same FW on the USB MCU. The difference is that the USB MCU will use the debug interface to read/write data of the SoC.
You can find board design files at CC2500EM_REFDES and CC2543EM-RD.
Regards,
Ryan
Yes, and you can review the SMARTRFTRXEBK User's Guide for more information. The CC2543 User's Guide contains a description of the debug interface.
Regards,
Ryan