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CC2538: The program can not be run .

Part Number: CC2538
Other Parts Discussed in Thread: FLASH-PROGRAMMER

Dear all

I had use SmartRF Flash Programmer 2 + xds110. but there are some questions about it.

1. After burning the program, the debugger connected to CC2538, CC2538 is powered off, then powered on, the program can be run normally,  but if the debugger is not connected to CC2538, the program can be not run normally .Why?

2. If I want to the program run normally, what can I do ? Is there some I/Os must be set high or low before power on ? or is there any configuration problem with the compiled project ?