We have decided to use two-wire RTD application as Fig.1. in application report of ADS1248 (as it looks like the first picture below) since our 1K RTDs are not far away (max 10cm line roughly equals 0.022ohm).But in this picture; it is only possible to read 4 RTDs.
But we have decided to use as in the second picture configuration since it is possible to read 5 RTDs and one extra signal to monitor.
It seems possible to read up to 7 RTDs as our configuration for the datasheet in Fig. 48 with 2 wire RTDs. But we want to make exactly sure about this. Also if this configuration is possible;what are the possible drawbacks if we compare to the attached first picture (4 RTD reading).