Tool/software:
we have used the TPA3110D2PWPR amplifier along with PoE from TI in our IP Speaker project. Got reviewed both the schematics and layout.
I am attaching the schematics of the project again for your reference. Our issue is that the on-board TI amplifier (TPA3110D2PWPR) is not producing any sound from the speaker.
We have also provided a provision to connect an external amplifier on the same board. When we connect the external amplifier, the audio output from the speaker works fine. This confirms that communication among CODEC, MPU, and external amplifier is proper. (Refer to the image below showing the external amplifier connection. Case2)
However, with the on-board TI amplifier, there is no audio output from the speaker. We have also implemented a gain control mechanism in the circuit. Please review the on-board amplifier circuit (shown below) and help us identify the issue. (case1) 
