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tusb9260 fullspeed connection and SPI

Other Parts Discussed in Thread: TUSB9260, TUSB9261

Hi,

When the TUSB9260 is connected to a USB 2.0 port, should pins 42,43,45,46 be left unconnected ? 

Could it work without SPI ? If so, what are the consequences and what should pins 17,18,20,21 be connected to ?

Thanks