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TUSB8043: Slave address not available in I2C master mode

Part Number: TUSB8043

Dear Team,

My customer is looking at TUSB8043 as USB Hub with GPIO feature. They want to control peripheral devices from the USB Hub with GPIO etc. 
Although the TUSB8043 can operate as I2C master mode, are there any Slave addresses which can not be used in the TUSB8043 application? 
I think that the EEPROM at bus address 1010000b can not be used. Are there any others?

One more question;
How many ports which can be used as GPIO does the TUSB8043 have?
How to set GPIO up?

I look forward to your reply.
Thank you.

Best Regards,

Koshi Ninomiya