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PCA9306: switch configuration with partial power down?

Part Number: PCA9306


Hi Team,

PCA9306 can be used in switch configuration. Vref1 and VREF2 shall be 3,3V each and the EN signal would be used to connect / disconnect.

Is it possible when the two busses are disconnected (EN low) to power off one side e.g. Vref2 without leakage currents say through the pull up resistors or other pats of the unpowered circuit?

In case this possible would the off- power side supply have to be High Z or does it need to connect to GND (0V) ?

many thanks

Lutz