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PCA9557, SCL/SDA states when VCC=0

Other Parts Discussed in Thread: TCA9509, PCA9557

My design has a PCA9557 I/O Expander sitting on a common I2C bus, but is powered from a different PS that could be 'off' in some circumstances (like during the initial start up phase).   If unpowered, will the SCA and SDA (pins 1 & 2) load down or clamp the I2C bus?      If so, would putting something like a TCA9509 in front of the PCA9557, with the Enable pin low whenever the other PS is 'off', be a solution?    Thanks.