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TS3USB221: Using TS3USB221 to switch between (2) hosts to downstream device

Part Number: TS3USB221

We are using a TS3USB221 to switch between (2) hosts and a downstream device.  Host #1 is connected to the 1D+/- pins.  Host #2 is connected to the 2D+/- pins.  The downstream device is connected to the D+/- pins. Upon power application the OE input pin is pulled low and the S input pin is pulled high connecting Host #2 to the downstream device.  To perform a switch over to Host #1 software clears the S input pin leaving the OE input pin low.  Each host computer is running Windows 10.  Switching from Host #2 to Host #1 rarely works however switching back from Host #1 to Host #2 always works.  Does anyone see an issue with this dessign approach?