Other Parts Discussed in Thread: TCA6416A
I have been trying to configure your TCA9539, but it is always NACKing back on the first byte(addressing). I am including a screen capture.
Bus Speed 400kHz
VCC - 3.3V
A0/A1 both are pulled high
SDA/SCLK are pulled with 4.7k resistors
I had been using the TCA6416A prior to using this device without any issues.