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TS3USB221A-Q1: Could we use it as 1 USB and 1 UART concept?

Part Number: TS3USB221A-Q1

Dear TI

I have question about TS3USB221A-Q1. 

It is USB2.0 MUX IC therefor need 2 USB Line.

But We will use port 1:USB Line  Port 2: UART Line(TX,RX).  

Question 1) Is it possible concept?  Could we use as 1 USB and 1 UART line MUX? 

                   (UART Voltage 1.8V or 3.3V)

Question2) If we didn't use low power mode (OE pin : high), How much consume the Current? 

     (VCC: high , S : High or Low)