1: Check power on reset sequence waveform for 3.3v ,1/1v and GRSTz pin and see if it meets hub power on reset sequence timing
2: Check voltage on USB_VBUS pin and see if the voltage is around 0.5v
3: Check if the crystal is oscillating after upstream port is connected to host
4: Do not enable SMBUSz with a pulldown unless a SMBUS host is used, otherwise the hub will hang waiting for configuration
5: Do not connect SDA/SCL to an on-board I2C bus unless it will be used
6: Do not leave blank EEPROMs connected to the hub if not used, the hub will enter a programming mode.
7: Please make sure the layout incorporates the thermal pad as shown in the datasheet.
8: If you still have issue, please submit E2E ticket with schematic to review