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TUSB8041: Connection and unpowered IC question

Part Number: TUSB8041

Is is safe to connect a PC's USB lead to an unpowered TUSB8041?
I have a powered down PCB that has to be left connected to a PC's USB port. The power to the TUSB8041 (3.3V and 1.1V) is supplied from the PCB not via the USB lead.

I would like to know if there is any problems leaving the live USB2 and USB3 signals connected to an unpowered TUSB8041 IC?


Thanks