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TUSB2046I: High and low speed operation configuration

Part Number: TUSB2046I

Tool/software:

For the4 port hub controller, TUSB2046IB,  is operation as both a high speed and low speed device simultaneously possible?

We chose to place the 1.5k ohm pullup to 3V3 on the DP line on the upstream side, to be able to operate Data storage and interactive LCDs but when a low speed mouse or keyboard is plugged in the all down stream ports are no longer working.