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PCA9306: Functionality Question

Part Number: PCA9306
Other Parts Discussed in Thread: SN74LVC2G66, TS5A23166, , LSF0002

Tool/software:

Hi, 

My customer had a question about whether this device would suit their application. They are looking to do the following: isolate an active I2C bus from an inactive I2C bus - even when powered down there should be no voltage on one of the Vref pins. (Non powered bus may be floating - so it is not connected to a power supply device)

Is this possible for the device? If so, what Vref should be used for the active bus? 

Thank you!