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TCA9509: Will I2C signals on the A side be isolated from B side if the B side is the only rail powered

Part Number: TCA9509

Tool/software:

For the TC9509, we have the B side connected to 3.3V and the A side connected to 1.8V.  During power on the 3.3V(side A) is powered up first.  This 3.3V voltage rail is also connected to the EN signal.  With the A side off and not yet powered, is it possible that the logic on the SCL/SDA side A could impact side B of the level shifter?  We are concerned about potential leakage of the signal on the B side from the A side.