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TUSB320LAI: TUSB320 Operation & unused pins

Part Number: TUSB320LAI
Other Parts Discussed in Thread: TUSB320, TUSB321

Please tell me about the TUSB320.
Is it possible to use it without utilizing I2C or GPIO for connecting to processors or other devices?
Also, if operation is possible without using I2C or GPIO, are there any requirements for handling the unused pins ?

-INT_N/OUT3(6)
-ADDR(5)
-SDA/OUT1(7)
-SCL/OUT(8)