Part Number: TXU0304
In the datasheet for the TXU0304 specific mention is made of isolation between power domains when turning the part partially off.
9.3.5 VCC Isolation and VCC Disconnect
The outputs for this device are disabled and enter a high-impedance state when either supply is <100 mV or left floating (disconnected), with the complementary supply within recommended operating conditions. It is recommended that the inputs are kept low before floating (disconnecting) either supply.
What is the effect of an input being high when the domain to which it is associated is turned off? Does it make a difference if the high GPIO falls with the supply voltage rail?