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ESD321: Can ESD321 protect 3.3V tolerant USB pins?

Part Number: ESD321
Other Parts Discussed in Thread: STRIKE

Hello, TI expert

 

ESD321 is designed to protect USB pins of STM32U595 MCU. As datasheet said USB pins are not always 5V tolerant. Sometimes it is 3.3V tolerant, in this case can ESD321 do pretection to ESD strikes?

 

BR

Yang