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PCA9306 for a battery powered application?

Other Parts Discussed in Thread: PCA9306

Hi, 

 I am planning to use the PCA9306 in a battery powered application. In this case the VREF1 will change between 2.7V and 3.6V depending the battery level. On VREF2 I will have a 3.3V generated by DC/DC converter that I can not use for I2C master device.

Is this a problem? It seems that VREF1 has to be always less than VREF2, is this right?

Do you have some advice or different components for this kind of application?

Thank you in advance,

Nicola